Got target?: computational methods for microRNA target prediction and their extension
نویسندگان
چکیده
منابع مشابه
Computational Methods for MicroRNA Target Prediction
MicroRNAs (miRNAs) are important players in gene regulation. The final and maybe the most important step in their regulatory pathway is the targeting. Targeting is the binding of the miRNA to the mature RNA via the RNA-induced silencing complex. Expression patterns of miRNAs are highly specific in respect to external stimuli, developmental stage, or tissue. This is used to diagnose diseases suc...
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Biochemistry 218: Computation Molecular Biology MicroRNAs (miRNAs) are non-coding, endogenous RNAs that make up a vast post-transcriptional regulatory network in cells. Processed from primary transcripts that are translated from miRNA genes, mature miRNAs are usually 19-25 nucleotides long. More than 4000 miRNAs have been identified in the genomes of over 80 species. Mature miRNAs are thought t...
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MicroRNAs (miRNAs) are 19 to 25 nucleotides non-coding RNAs known to possess important post-transcriptional regulatory functions. Identifying targeting genes that miRNAs regulate are important for understanding their specific biological functions. Usually, miRNAs down-regulate target genes through binding to the complementary sites in the 3' untranslated region (UTR) of the targets. In part, du...
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Background: Micro RNAs (miRNAs) are a pivotal part of non-protein-coding endogenous small RNA molecules that regulate the genes involved in plant growth and development, and respond to biotic and abiotic environmental stresses posttranscriptionally.Objective: In the present study, we report the results of a systemic search for identifi cation of new miRNAs in B. rapa using homology-based ...
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In this chapter, we review evidence that at least three different types of microRNA (miRNA)-messenger RNA (mRNA) target interactions exist in mammals: short seeds, long seeds, and "perfect" hits (allowing G:U matches). Because new types of miRNAs are still being discovered, this list may not yet be complete.
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ژورنال
عنوان ژورنال: Experimental and Molecular Medicine
سال: 2010
ISSN: 1226-3613
DOI: 10.3858/emm.2010.42.4.032